產(chǎn)品編號 yb-0576R
英文名稱 Anti-Annexin A2抗體
中文名稱 膜粘連蛋白 Ⅱ抗體
別    名 Annexin A2; ANX 2; ANX2; ANX2L4; ANXA2; arylsulfatase B; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide (p36); chromobindin 8; LIP2; Lipocortin II; LPC2; LPC2D; P36; P36 protein; PAP-IV; placental anticoagulant protein IV; Protein I; ANXA2_HUMAN; Annexin II; Annexin-2; Calpactin-1 heavy chain; Chromobindin-8; Placental anticoagulant protein IV.
Anti-Annexin A2抗體 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Annexin II
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Subunit:
Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF. Interacts with human cytomegalovirus (HCMV). Interacts with COCH.

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.

Post-translational modifications:
Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. 
ISGylated.

Similarity:
Belongs to the annexin family.
Contains 4 annexin repeats.

是新近發(fā)現(xiàn)的纖維蛋白溶解酶原(PLG)和組織型纖溶蛋白溶解酶原激活物(t-PA)的共受體,是Ca2+介導(dǎo)具有高親和力的磷脂結(jié)合蛋白.其介導(dǎo)血管內(nèi)外纖維蛋白溶解,對保持機(jī)體內(nèi)環(huán)境穩(wěn)定具有重要作用.
依賴性膜磷脂結(jié)合蛋白Annexin II調(diào)控異常及有害因子的作用,可導(dǎo)致血栓性疾病和動脈硬化癥
鈣依賴性膜磷脂結(jié)合蛋白膜粘連蛋白2異常高表達(dá)所引起纖溶亢進(jìn),是白血病等惡性腫瘤出血合并癥重要機(jī)制之一.鈣依賴性磷脂結(jié)合蛋白對其干預(yù)和調(diào)控可能為治療上述病癥提供新思路,為臨床治療開辟新途徑.