產(chǎn)品編號 yb-0634R
英文名稱 Anti-Aquaporin 4抗體
中文名稱 水通道蛋白4抗體
別    名 aquaporin 4; WCH4; Mercurial-insensitive water channel; MIWC; AQP 4; AQP4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; MGC22454; MIWC; AQP4_HUMAN; Aquaporin-4; AQP-4.
Anti-Aquaporin 4抗體
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 神經(jīng)生物學(xué)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AQP4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.

Subunit:
Homotetramer. Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Brain, muscle, heart, kidney, lung, and trachea.

Similarity:
Belongs to the MIP/aquaporin (TC 1.A.8) family.


水通道蛋白(AQPs)廣泛分布于機體不同組織器官中,腦組織中的水通道蛋白主要為AQP4.
AQP-4蛋白主要在星型膠質(zhì)細(xì)胞和室管膜細(xì)胞內(nèi)表達,尤其在于毛細(xì)血管和軟腦膜直接接觸的膠質(zhì)細(xì)胞上及血管周表達豐富.
水通道蛋白4的分布特點與其功能密切相關(guān),可能是腦脊液重吸收、滲透壓調(diào)節(jié)、腦水腫形成等生理、病理過程的分子生物學(xué)基礎(chǔ).研究水通道蛋白4可為腦水腫及水代謝疾病提供分子水平的理論依據(jù),同時為臨床治療腦水腫及水代謝疾病提供一種新途徑.